The management of ventricular arrhythmias in cardiac amyloidosis lacks robust guideline recommendations, with ICD therapy potentially beneficial primarily in the early stages of AL amyloidosis.
Cardiac amyloidosis (CA) is an infiltrative cardiomyopathy that occurs secondary to deposition of misfolded protein in the myocardium. The two most common subtypes are amyloid light chain amyloidosis and amyloid transthyretin amyloidosis. CA frequently results in congestive cardiac failure and arrhythmias, due to a disruption in cardiac substrate with subsequent electromechanical remodeling. Disease progression is usually demonstrated by development of progressive pump failure, which may be seen with a high arrhythmic burden, usually portending a poor prognosis. Arrhythmias are ...
Dumont et al. (Fri,) studied this question.