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Abstract An atom and step economy cascade trifluoromethylation/cyclization of unactivated alkene with Langlois reagent as a CF 3 source is described. A variety of polycyclic quinazolinones were successfully synthesized in 52–81% yields under transition metal‐ and oxidant‐free conditions. The Langlois reagent used in this strategy as a CF 3 reagent possesses the advantages of bench‐stablity, cost‐effectivity and high‐efficiency. Additionally, gram‐scale reaction, broad substrate scope and good functional group tolerance demonstrated the synthetic usefulness of this protocol. magnified image
Liu et al. (Tue,) studied this question.