Baseline left ventricular wall motion abnormalities were associated with a significantly higher risk of incident heart failure (HR 3.63; 95% CI 2.15-6.12; p<0.001) independent of ejection fraction.
Cohort (n=3,415)
Does the presence of wall motion abnormalities or increased global WMSI predict incident heart failure in adults without known heart failure or ischemic heart disease?
Wall motion abnormalities and increased global WMSI on echocardiography independently predict long-term incident heart failure in the general population without prior heart failure or ischemic heart disease.
Effect estimate: HR 3.63 (95% CI 2.15-6.12)
p-value: p=<0.001
BACKGROUND: Wall Motion Score Index (WMSI) is a simple method to quantify global and regional systolic function on echocardiography. We sought to investigate the prognostic importance of global and regional WMSI for the development of incident heart failure (HF) in the general population. METHODS: We included adults without HF or ischemic heart disease from the 4th Copenhagen City Heart Study (2001-2003). At baseline, participants underwent an echocardiography and physical examination and completed a self-administered health questionnaire. WMSI was assessed by conventional echocardiography using a 16-segment model obtaining WMSI assessments for the anterior, lateral, inferior, septal, and posterior left ventricular (LV) walls and calculating a global WMSI. The primary endpoint was incident HF. RESULTS: Among 3415 participants (mean age 58 years, 42% male, 45% with hypertension), 83 (2.4%) had hypo-, a-, or dyskinesia of at least one LV wall segment at baseline. During a median follow-up of 15.4 years, 297 (8.7%) participants developed HF. After adjusting for important clinical variables, LV ejection fraction and E/A, hypo-, a- or dyskinesia of at least one segment in any of the LV regional walls was associated with a higher risk of incident HF (HR 3.63, 95% CI 2.15-6.12, p < 0.001). Similarly, global WMSI was independently associated with a higher risk of HF (HR 1.38 per 0.1 increase, 95%CI 1.22-1.56, p < 0.001). CONCLUSION: Wall motion abnormalities in any regional LV wall and global WMSI were associated with incident HF in this general population cohort independent of various baseline clinical data, LV ejection fraction and E/A.
Espersen et al. (Tue,) conducted a cohort in General population without heart failure or ischemic heart disease (n=3,415). Left ventricular wall motion abnormalities (hypo-, a-, or dyskinesia) vs. Normal wall motion was evaluated on Incident heart failure (HR 3.63, 95% CI 2.15-6.12, p=<0.001). Baseline left ventricular wall motion abnormalities were associated with a significantly higher risk of incident heart failure (HR 3.63; 95% CI 2.15-6.12; p<0.001) independent of ejection fraction.