Obstructive sleep apnea signs, including a higher apnea-hypopnea index (24.6 vs 10.3, p<0.001), and greater airflow limitation were independently associated with endothelial dysfunction.
Observational (n=113)
No
Are obstructive sleep apnea signs and airflow limitation associated with endothelial dysfunction in patients undergoing diagnostic coronary angiography?
Obstructive sleep apnea signs and airflow limitation are independent predictors of endothelial dysfunction in patients undergoing coronary angiography, regardless of CAD severity.
Absolute Event Rate: 24.6% vs 10.3%
p-value: p=<0.001
Background: Obstructive sleep apnea is associated with an increased prevalence of cardiovascular disease. The mechanism of these associations is not completely understood. We aimed to investigate the association of the apnea hypopnea index and the degree of airflow limitation with endothelial dysfunction. Methods: This was a single-center prospective study of patients admitted for diagnostic coronary angiography (CAG). Endothelial function was assessed by the non-invasive EndoPAT system by reactive hyperemia index (RHI) and divided into two groups: endothelial dysfunction and normal endothelial function. Sleep apnea signs were detected by WatchPAT measuring the respiratory disturbance index (pRDI), the apnea and hypopnea index (pAHI), and the oxygen desaturation index (ODI). Patients underwent spirometry and body plethysmography. Based on CAG, the severity of coronary artery disease was assessed as follows: no significant coronary artery disease, single-, two- and three-vessel disease. Results: A total of 113 patients were included in the study. Breathing disorders measured by WatchPAT and spirometry were more severe in patients with endothelial dysfunction: pRDI (27.3 vs. 14.8, p = 0.001), pAHI (24.6 vs. 10.3, p < 0.001), ODI (13.7 vs. 5.2, p = 0.002), forced expiratory volume in one second (FEV1) (81.2 vs. 89, p = 0.05). In a multivariate regression analysis, pAHI and FEV1 were independent predictors of endothelial dysfunction assessed by RHI. There was no correlation between the severity of coronary artery disease and endothelial dysfunction. Conclusions: Obstructive sleep apnea signs and greater airflow limitation were associated with endothelial dysfunction regardless of the severity of the coronary artery disease.
Ochijewicz et al. (Thu,) conducted a observational in Patients undergoing diagnostic coronary angiography (n=113). Obstructive sleep apnea and airflow limitation vs. Normal endothelial function was evaluated on Apnea and hypopnea index (pAHI) in patients with endothelial dysfunction versus normal endothelial function (p=<0.001). Obstructive sleep apnea signs, including a higher apnea-hypopnea index (24.6 vs 10.3, p<0.001), and greater airflow limitation were independently associated with endothelial dysfunction.