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thus qualify as specific chemical probes to explore PI3Kα-selective signaling branches. The proposed approach is generally suited to develop covalent tools targeting distal, unexplored Cys residues in biologically active enzymes.
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Chiara Borsari
Erhan Keleş
Jacob A. McPhail
Journal of the American Chemical Society
ETH Zurich
University of Basel
University of Victoria
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Borsari et al. (Wed,) studied this question.
www.synapsesocial.com/papers/69ffd0556be84a7ac885568c — DOI: https://doi.org/10.1021/jacs.1c13568
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