Does first-line therapy with drug combinations improve survival in adults with pulmonary arterial hypertension?
Adults with pulmonary arterial hypertension
First-line therapy with drug combinations that target multiple biological pathways
No treatment
Survivalhard clinical
First-line combination therapy targeting multiple biological pathways is associated with improved survival in patients with pulmonary arterial hypertension.
Pulmonary arterial hypertension affects an estimated 10.6 per 1 million adults in the US and, without treatment, typically progresses to right heart failure and death. First-line therapy with drug combinations that target multiple biological pathways are associated with improved survival.
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Nicole F. Ruopp
Tufts Medical Center
Barbara A. Cockrill
Harvard University
JAMA
Harvard University
Brigham and Women's Hospital
Tufts Medical Center
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Ruopp et al. (Tue,) studied this question.
synapsesocial.com/papers/69db928e4e9a02dbaa685585 — DOI: https://doi.org/10.1001/jama.2022.4402