A higher fat mass index in late midlife was associated with worse vascular health 15 years later (β 0.15), which was not ameliorated by a higher lean mass index.
Cohort (n=660)
No
Do adiposity-related factors and body composition predict vascular aging (pulse wave velocity) 15 years later in older adults?
Adiposity-related factors, particularly fat mass index, are strong predictors of vascular aging and arterial stiffness later in life, and this risk is not offset by having a higher lean mass index.
Effect estimate: β 0.15 (95% CI 0.05-0.24)
p-value: p=0.002
The main objective of this study was to study predictors of vascular health with focus on adiposity-related factors. Glucose metabolism, blood lipids, inflammatory markers and body composition were assessed 15 years before assessment of vascular health which was assessed with pulse wave velocity (PWV) in 660 subjects born 1934-44. In a univariate analysis in women the strongest association with PWV was seen for age, systolic blood pressure, dysglycemia, dyslipidemia, inflammatory markers and body fat percentage measured in late midlife and PWV measured 15 years later. In men age, body mass index (BMI), systolic blood pressure, dysglycemia, and body fat percentage in late midlife were associated with PWV. One novel finding was that adiposity-related factors were strong predictors of vascular health, something not fully encapsulated in BMI, lean body mass or body fat percentage alone. A higher fat mass index was associated with worse vascular health, which was not ameliorated by a higher lean mass index. Our findings stress the importance to study body composition and fat and lean body mass simultaneously because of their close interaction with each other also in relation to vascular health.
Eriksson et al. (Thu,) conducted a cohort in Vascular aging (n=660). High fat mass index and low lean mass index vs. Low fat mass index and high lean mass index was evaluated on Carotid-femoral pulse wave velocity (CFPWV) at 15-year follow-up (β 0.15, 95% CI 0.05-0.24, p=0.002). A higher fat mass index in late midlife was associated with worse vascular health 15 years later (β 0.15), which was not ameliorated by a higher lean mass index.