Does aqueous leaf extract of Solanum macrocarpon ameliorate diabetic cardiomyopathy in alloxan-induced diabetic rats?
Solanum macrocarpon aqueous leaf extract may ameliorate diabetic cardiomyopathy by attenuating oxidative stress and inflammation in a rat model.
In this research, the beneficial roles of aqueous leaf extract of Solanum macrocarpon (SM) on diabetic cardiomyopathy were evaluated. Diabetic rats (induced with alloxan) were given varying doses of SM aqueous leaves extract for 28 days, and the animals were sacrificed. A series of diabetic cardiomyopathy parameters were determined. Diabetic rats showed hyperglycemia, hyperlipidemia, with a momentous upsurge in lactate dehydrogenase, creatine kinase, cardiac troponin I activities as well as inflammatory markers. Also, diabetic rats demonstrated a substantial decline in the activities of antioxidant enzymes in relation to other groups. Administration of different doses of SM aqueous leaf extract to diabetic rats demonstrated normoglycemia, normolipidemia, reduced the activities of lactate dehydrogenase, creatine kinase, cardiac troponin I, and inflammatory levels as well as an increase in the antioxidant enzyme activities. In conclusion, the results suggest that SM aqueous leaf extract ameliorates diabetic cardiomyopathy. PRACTICAL APPLICATIONS: This study examined the role of Solanum macrocarpon (SM) aqueous leaf extract in diabetic cardiomyopathy. Results revealed that SM might be useful in ameliorating diabetic cardiomyopathy.
Osukoya et al. (Mon,) studied this question.