Hypertension was associated with a 19% increased risk of incident dementia (HR 1.19; 95% CI 1.11-1.27), regardless of genetic risk.
Cohort (n=198,965)
Does hypertension increase the risk of incident dementia in dementia-free adults aged ≥60 years?
Hypertension is associated with an increased risk of incident dementia regardless of underlying genetic risk.
Hazard Ratio: 1.19 (95% CI 1.11–1.27)
INTRODUCTION: There is inconsistent evidence on whether genetic risk for dementia modifies the association between hypertension and dementia. METHODS: In 198,965 dementia-free participants aged ≥60 years, Cox proportional-hazards models were used to investigate the association between hypertension and incident dementia. A polygenic risk score (PRS) based on 38 non-apolipoprotein E (APOE) single nucleotide polymorphisms and APOE ε4 status were used to determine genetic risk for dementia. RESULTS: Over 15 years follow-up, 6270 participants developed dementia. Hypertension was associated with a 19% increased risk of dementia (hazard ratio = 1.19, 95% confidence interval 1.11-1.27). The associations remained similar when stratifying by genetic risk, with no evidence for multiplicative interaction by dementia PRS (P = 0.20) or APOE ε4 status (P = 0.16). However, the risk difference between those with and without hypertension was larger among those at higher genetic risk. DISCUSSION: Hypertension was associated with an increased risk of dementia regardless of genetic risk for dementia.
Littlejohns et al. (Tue,) conducted a cohort in Dementia (n=198,965). Hypertension vs. Without hypertension was evaluated on Incident dementia (HR 1.19, 95% CI 1.11-1.27). Hypertension was associated with a 19% increased risk of incident dementia (HR 1.19; 95% CI 1.11-1.27), regardless of genetic risk.