Female sex was associated with higher mortality than male sex in AMI-CS patients aged 45-84 and non-AMI-CS patients aged 20-84 (e.g., AMI-CS 65-84 years: 39.3% vs 37.9%; p<0.01).
Observational (n=1,506,281)
Yes
Does female sex affect the incidence, management, and mortality of cardiogenic shock across different age groups compared to male sex?
Females experience a lower incidence of cardiogenic shock but suffer higher mortality and disparities in management compared to males, particularly between ages 45 and 84.
p-value: p=<0.01
BACKGROUND: There is a lack of data on age-stratified sex differences in the incidence, treatment, and outcomes of cardiogenic shock (CS). We sought to study these differences from a contemporary database. METHODS: Patients admitted with CS (2004-2018) were identified from the United States National Inpatient Sample. We compared CS (acute myocardial infarction-related cardiogenic shock AMI-CS and non-acute myocardial infarction-related cardiogenic shock Non-AMI-CS) incidence, management, and outcomes in males and females, stratified into four age groups (20-44, 45-64, 65-84, and ≥85 years of age). Propensity score matching (PSM) was used for adjustment. RESULTS: A total of 1,506,281 weighted hospitalizations for CS were included (AMI-CS, 39%; Non-AMI-CS, 61%). Across all age groups, females had a lower incidence of CS compared with males. After PSM and among the AMI-CS cohort, higher mortality among females compared with males was observed in the age groups 45-64 (28.5% vs. 26.3%) and 65-84 years (39.3% vs. 37.9%) (p < 0.01, for all). Among the Non-AMI-CS cohort, higher mortality among females compared with males was observed in the age groups 20-44 (33.5% vs. 30.5%), 45-64 (35.1% vs. 31.9%), and 65-84 years (41.7% vs. 40.3%) (p < 0.01, for all). Similar age-dependent differences in the management of CS were also observed between females and males. CONCLUSIONS: Females have a lower incidence of CS regardless of age. Significant disparities in the management and outcomes of CS were observed based on sex. However, these disparities varied by age and etiology of CS (AMI-CS vs. Non-AMI-CS) with pronounced disparity among females in the age range of 45-84 years.
Osman et al. (Thu,) conducted a observational in Cardiogenic shock (n=1,506,281). Female sex vs. Male sex was evaluated on Mortality (p=<0.01). Female sex was associated with higher mortality than male sex in AMI-CS patients aged 45-84 and non-AMI-CS patients aged 20-84 (e.g., AMI-CS 65-84 years: 39.3% vs 37.9%; p<0.01).
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