Beta-blockers were not significantly associated with long-term all-cause mortality in post-MI patients without heart failure and LVEF ≥50% (HR 1.17; 95% CI 0.70-1.94; P=0.547).
Cohort (n=2,519)
Yes
Effect estimate: HR 1.17 (95% CI 0.70-1.94)
p-value: p=0.547
BACKGROUND: The role of beta-blockers in acute myocardial infarction patients without heart failure and with preserved left ventricular ejection fraction (LVEF ≥ 50%) is unknown. Our study aimed to retrospectively analyze the associations of beta-blockers on such patients. METHODS: This is a multicenter, retrospective study. After screening 5,332 acute myocardial infarction patients, a total of 2519 patients without heart failure and with LVEF ≥ 50% were included. The patients were divided into two groups: the prescribed (n = 2049) and unprescribed (n = 470) beta-blockers group. The propensity score inverse probability treatment weighting was used to control confounding factors. We analyzed the associations between beta-blockers and outcomes in the short-term (1-year) and long-term (median, 3.61 years). RESULTS: The primary outcome was all-cause mortality. The secondary outcomes were all-cause rehospitalization, cardiac death, recurrent myocardial infarction, new-onset heart failure rehospitalization. This study shows no statistically significant association between discharged with beta-blockers and all-cause mortality, either in the short-term IPTW Adjusted, HR 1.02; 95%CI 0.43-2.40; P = 0.966 or long-term IPTW Adjusted, HR 1.17; 95%CI 0.70-1.94; P = 0.547. Discharged with beta-blockers was significantly associated with a reduced risk of short-term recurrent myocardial infarction IPTW Adjusted, HR 0.44; 95%CI 0.20-0.97; P = 0.043, but there was no long-term relationship IPTW Adjusted, HR 1.11; 95%CI 0.61-2.03; P = 0.735. Other outcomes, such as new-onset heart failure rehospitalization and all-cause rehospitalization, were not observed with meaningful differences in either the short- or long-term. The results of sensitivity analysis were consistent with this. CONCLUSIONS: Beta-blockers might be associated with a reduced risk of recurrent myocardial infarction in patients without heart failure and with preserved left ventricular ejection fraction after acute myocardial infarction, in the short term. Beta-blockers might not be related to all-cause mortality in those patients, either in the short-term or long-term. Clinical trial registration Influence of Beta-blockers on Prognosis in Patients with Acute Myocardial Infarction Complicated with Normal Ejection Fraction, NCT04485988, Registered on 24/07/2020. Retrospectively registered.
Wen et al. (Tue,) conducted a cohort in Acute myocardial infarction without heart failure and with preserved ejection fraction (n=2,519). Beta-blockers vs. Unprescribed beta-blockers was evaluated on All-cause mortality (HR 1.17, 95% CI 0.70-1.94, p=0.547). Beta-blockers were not significantly associated with long-term all-cause mortality in post-MI patients without heart failure and LVEF ≥50% (HR 1.17; 95% CI 0.70-1.94; P=0.547).