Metabolic syndrome was associated with a higher prevalence of left ventricular diastolic dysfunction compared to no metabolic syndrome (0.56% vs 0.27%; OR 1.350, 95% CI 1.103-1.652).
Cohort (n=148,461)
Is metabolic syndrome associated with left ventricular diastolic dysfunction in adults undergoing health screening?
Metabolic syndrome, particularly elevated triglycerides and waist circumference, is independently associated with an increased risk of left ventricular diastolic dysfunction in men.
Odds Ratio: 1.35 (95% CI 1.103–1.652)
Absolute Event Rate: 0.56% vs 0.27%
p-value: p=<0.001
BACKGROUND: We investigated the association between individual components of metabolic syndrome (MetS) and left ventricular (LV) geometric changes, including diastolic dysfunction, in a large cohort of healthy individuals. METHODS: Overall, 148 461 adults who underwent echocardiography during a health-screening program were enrolled. Geographic characteristics on echocardiography and several markers of LV relaxation function were identified according to individual MetS components. Univariate linear regression analysis and a multivariate regression model adjusted for factors known to influence LV relaxation function were conducted. RESULTS: The prevalence of LV diastolic dysfunction (LVDD) was higher in the MetS group than in the non-MetS group (0.56% vs. 0.27%, p < .001). In univariate and multivariate analyses, E/A ratio, e' velocity, and left atrial volume index were significantly associated with each component of MetS and covariates (all p ≤ .001). In the age- and sex-adjusted model, MetS was significantly associated with LVDD (odds ratio 95% confidence interval, 1.350 1.103, 1.652). However, subjects with more MetS components did not have a significantly higher risk of LVDD. As the analysis was stratified by sex, the multivariate regression model showed that MetS was significantly associated with LVDD only in men (1.3 1.00, 1.68) with higher risk in more MetS component (p for trend < .001). In particular, triglyceride (TG) and waist circumference (WC) among MetS components were significantly associated with LVDD in men. CONCLUSIONS: MetS was associated with the risk of LVDD, especially in men, with a dose-dependent association between an increasing number of components of MetS and LVDD. TG and WC were independent risk factors for LVDD in men.
Lee et al. (Tue,) conducted a cohort in Metabolic syndrome (n=148,461). Metabolic syndrome vs. No metabolic syndrome was evaluated on Left ventricular diastolic dysfunction (LVDD) (OR 1.350, 95% CI 1.103-1.652, p=<0.001). Metabolic syndrome was associated with a higher prevalence of left ventricular diastolic dysfunction compared to no metabolic syndrome (0.56% vs 0.27%; OR 1.350, 95% CI 1.103-1.652).