Both greater left atrioventricular coupling index (LACI) and average change in LACI were independently associated with a 69% increased risk of incident atrial fibrillation (HR 1.69, 1.71).
Do left atrioventricular coupling index (LACI) and its annualized change measured by cardiac MRI predict incident atrial fibrillation in individuals without baseline cardiovascular disease?
Left atrioventricular coupling index and its annualized change measured by cardiac MRI provide incremental prognostic value over traditional risk factors for predicting incident atrial fibrillation.
Absolute Event Rate: 0% vs 0%
Background Left atrial (LA) and left ventricular (LV) structural and functional parameters have independent prognostic values as predictors of atrial fibrillation (AF). Purpose To investigate the prognostic value of a left atrioventricular coupling index (LACI) and average annualized change in LACI (hereafter, ΔLACI) measured by cardiac MRI to predict incident AF in a population-based sample from the Multi-Ethnic Study of Atherosclerosis (MESA). Materials and Methods In a secondary analysis of the prospective MESA, 1911 study participants without clinically recognized AF and cardiovascular disease at baseline had LACI assessed with cardiac MRI at baseline (examination 1, 2000-2002) and 10 years later (examination 5, 2010-2012). LACI was defined as the ratio of LA to LV end-diastolic volumes. Univariable and multivariable Cox proportional hazard models were used to evaluate the associations of LACI and average ΔLACI with incident AF. Results Among the 1911 participants (mean age, 59 years ± 9 standard deviation; 907 men), 87 incident AF events occurred over 3.9 years ± 0.9 after the second imaging (examination 5). After adjustment for traditional risk factors, greater LACI and ΔLACI were independently associated with AF (hazard ratio, 1.69 95% CI: 1.46, 1.96 and 1.71 95% CI: 1.50, 1.94, respectively; both P P P Online supplemental material is available for this article. See also the editorial by Leiner in this issue.
Pezel et al. (Tue,) reported a other. Both greater left atrioventricular coupling index (LACI) and average change in LACI were independently associated with a 69% increased risk of incident atrial fibrillation (HR 1.69, 1.71).