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This comprehensive account of the genetic and environmental factors that cause atopic dermatitis reconciles two hypotheses concerning the origin of the disease — IgE-mediated sensitization, or an intrinsic defect in epithelial cells that causes dysfunction of the skin barrier — with evidence that both mechanisms contribute. Clinical implications are discussed.
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Thomas Bieber (Wed,) studied this question.
www.synapsesocial.com/papers/69df42d7915fa049536141f5 — DOI: https://doi.org/10.1056/nejmra074081
Thomas Bieber
New England Journal of Medicine
University of Bonn
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