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Randomized trials have traditionally been broadly categorized as either an effectiveness trial or an efficacy trial, although we prefer the terms “pragmatic” and “explanatory.” Schwartz and Lellouch described these 2 approaches toward clinical trials in 1967. 11 These authors coined the
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Canadian Medical Association Journal
University of Toronto
Sunnybrook Health Science Centre
Health Sciences Centre
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Thorpe et al. (Thu,) studied this question.