Electrocardiographic left ventricular hypertrophy was associated with an increased risk of major cardiovascular events compared to those without ECG-LVH (19.0% vs 15.6%; P=0.0023).
Cohort (n=9,541)
Does the presence of electrocardiographic left ventricular hypertrophy predict mortality and cardiovascular morbidity in high-risk patients with established cardiovascular diseases?
Simple ECG criteria for LVH independently identify a subset of high-risk cardiovascular patients at particularly increased risk for death and heart failure.
Absolute Event Rate: 19% vs 15.6%
p-value: p=0.0023
The prognostic significance of left ventricular hypertrophy (LVH) identified by simple electrocardiographic (ECG) criteria in high-risk patients with established cardiovascular (CV) diseases is not clearly understood.The Heart Outcomes Prevention Evaluation (HOPE) trial was a randomized trial, which evaluated the effects of ramipril and of vitamin E on major CV outcomes in 9541 men and women aged 55 years or older with a history of coronary artery disease, stroke, peripheral vascular disease or diabetes mellitus with at least one additional CV risk factor. Patients were followed for an average of 4.5 years. We evaluated the association between simple ECG criteria for LVH and the risk for major vascular events, for CV and all-cause mortality and for heart failure.Electrocardiographic LVH was present in 793 (8.3%) HOPE study participants. Of these, 19.0% sustained a major CV event (MI, stroke or CV death), 15.6% died and 6.1% developed heart failure compared with 15.6%, 10.8% and 2.9% respectively of those without ECG-LVH (P = 0.0023; P < 0.0001 and P < 0.0001). In multivariate analysis ECG-LVH was an independent predictor of CV and all-cause death and of heart failure.In patients with CV disease simple, easily applicable ECG criteria for LVH identify a subset of individuals at particularly high risk for death and for heart failure.
Lonn et al. (Mon,) conducted a cohort in Cardiovascular disease (n=9,541). Electrocardiographic left ventricular hypertrophy (ECG-LVH) vs. No ECG-LVH was evaluated on Major CV event (MI, stroke or CV death) (p=0.0023). Electrocardiographic left ventricular hypertrophy was associated with an increased risk of major cardiovascular events compared to those without ECG-LVH (19.0% vs 15.6%; P=0.0023).