Younger patients (≤40 years) with acute myocardial infarction had significantly lower 6-month mortality than older patients (3.1% vs 12%, P<0.001), with smoking being a highly prevalent risk factor.
Cohort (n=8,056)
Yes
Do younger patients (≤ 40 years) with acute myocardial infarction have different baseline characteristics and outcomes compared to older patients (> 40 years)?
Young patients with acute myocardial infarction have better outcomes than older patients, largely due to better baseline characteristics, but have a significantly higher prevalence of smoking and family history of cardiovascular disease.
Absolute Event Rate: 3.1% vs 12%
p-value: p=<0.001
Patients who received thrombolytic therapy for acute myocardial infarction in a large international trial were divided into two groups on the basis of age; those ≤ 40 years (n=269) and those >40 years (n = 7787). The younger group included more men (89.9% vs 75.9%, P=0.009) and fewer patients had a history of coronary artery disease, hypertension, and diabetes mellitus. A family history of cardiovascular disease was significantly more prevalent among the young patients (53.4% vs 41.9%, P=0.0002). Significantly more younger patients than older patients were smokers at the time of infarction (76.2% vs 42.9%, P1 in 4.5% vs 8.0%, P<0.001), and lower hospital and 6-month mortality (0.7% and 3.1% vs 8.3% and 12%, P<0.001, respectively). The better outcome of younger patients with acute myocardial infarction is related to their better baseline characteristics. Young patients with acute myocardial infarction have a strong family history of cardiovascular disease and a high prevalence of smoking. Smoking is the most important modifiable risk factor in these patients.
FOR THE INVESTIGATORS OF THE INTERNATIONAL TISSUE PLASMINOGEN ACTIVATOR STREPTOKINASE MORTALITY TRIAL (Wed,) conducted a cohort in Acute myocardial infarction (n=8,056). Age ≤ 40 years vs. Age > 40 years was evaluated on 6-month mortality (p=<0.001). Younger patients (≤40 years) with acute myocardial infarction had significantly lower 6-month mortality than older patients (3.1% vs 12%, P<0.001), with smoking being a highly prevalent risk factor.