European recommendations on organisation of interventional care in acute stroke (EROICAS)

The group identified all available related literature and selected eligible studies.For each question, three to five authors (Appendix) screened the publications and assessed the full text of potentially relevant studies.We restricted our evidence synthesis to RCTs, systematic reviews and meta-analyses of RCTs relating to 15 questions.The group graded quality of evidence and strength of recommendations.The final summaries of the quality and strength of evidence and recommendations for each question (based on RCT evidence only) were discussed by the whole group, and the recommendations were agreed by a majority consensus of the group of all authors.Similar to the GRADE approach, 15 quality of evidence was graded into high, moderate, low, and very low.Overall, 41 recommendations were given.Section authors generated ''additional information'' based on RCTs and observational studies.Development of guidelines that encompasses the GRADE guideline development process 151617 is under way.