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This review of Alzheimer's disease assembles a variety of findings relevant to the mechanism of the disease and ties them together using the current understanding of the basis of the loss of cognition: the accumulation of misfolded proteins, which cause oxidative and inflammatory damage to the brain and, ultimately, synaptic dysfunction.
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Henry Querfurth
Frank M. LaFerla
New England Journal of Medicine
University of California, Irvine
Brown University
Tufts Medical Center
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Querfurth et al. (Wed,) studied this question.
www.synapsesocial.com/papers/69d777e5ef4aa71f97f31670 — DOI: https://doi.org/10.1056/nejmra0909142