Alterations in myocardial fuel selection and energetics, particularly involving the PGC-1alpha/PPARalpha regulatory pathway, are linked to the development and progression of heart failure.
The mitochondrion serves a critical role as a platform for energy transduction, signaling, and cell death pathways relevant to common diseases of the myocardium such as heart failure. This review focuses on the molecular regulatory events and downstream effector pathways involved in mitochondrial energy metabolic derangements known to occur during the development of heart failure.
Huss et al. (2005) conducted a review in Heart failure. Alterations in myocardial fuel selection and energetics, particularly involving the PGC-1alpha/PPARalpha regulatory pathway, are linked to the development and progression of heart failure.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: