High metabolic risk combined with the least healthy lifestyle significantly increased the risk of incident cardiovascular disease (HR 2.06) compared to low metabolic risk and the most healthy lifestyle.
Cohort (n=94,831)
Yes
Does a healthy lifestyle and low metabolic risk reduce incident cardiovascular disease and all-cause mortality in adults without a history of cardiovascular disease?
Adherence to a healthy lifestyle is associated with a lower risk of cardiovascular disease and all-cause mortality, regardless of baseline metabolic risk status.
Effect estimate: HR 2.06 (95% CI 1.77-2.39)
Abstract Purpose: We investigated the joint associations of modifiable lifestyle and metabolic factors with incident cardiovascular disease and all-cause mortality. Methods: This study included 94,831 participants (men, 79.76%; median age, 51.60 43.47-58.87) without a history of cardiovascular disease at baseline from Kailuan study during 2006 to 2007 and followed them until new-onset cardiovascular disease event, death or December 31, 2017. Baseline metabolic health status was assessed by Adult Treatment Panel-III criteria and five lifestyle factors was collected using a self-reported questionnaire. We performed Cox proportional hazards models to evaluate the joint associations. Results: During a median follow-up of 11.03 years, we observed 6,590 cardiovascular disease events and 9,218 all-cause mortality. Participants within more metabolic risk components and least healthy lifestyle had the highest cardiovascular disease risk (hazard ratio 2.06 95% CI 1.77-2.39) and mortality risk (hazard ratio 1.53 95% CI 1.31-1.78), as compared with the less metabolic risk components and most healthy lifestyle group. Compared with the most healthy lifestyle, the hazard ratio of cardiovascular disease for participants with least healthy lifestyle was 1.26 (95% CI 1.17–1.37) in the category with low metabolic risk, 1.16 (95% CI 1.03–1.31) and 1.07 (95% CI 0.90–1.27) for those with medium and high metabolic risk, respectively. Conclusions: We showed that healthy lifestyle was associated with a lower risk of cardiovascular disease and there was no significant interaction between metabolic risk and healthy lifestyle. Our results indicated that healthy lifestyle should be promoted even for people with high metabolic risk.
Zuo et al. (Thu,) conducted a cohort in General population without cardiovascular disease (n=94,831). High metabolic risk and least healthy lifestyle vs. Low metabolic risk and most healthy lifestyle was evaluated on Incident cardiovascular disease (HR 2.06, 95% CI 1.77-2.39). High metabolic risk combined with the least healthy lifestyle significantly increased the risk of incident cardiovascular disease (HR 2.06) compared to low metabolic risk and the most healthy lifestyle.