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Our study indicates that HE4 may participate in airway inflammation and remodeling of COPD. Cigarette smoke enhances HE4 expression and secretion in bronchial epithelium mediated by oxidative stress. Increased HE4 promotes IL-6 release in HBE via phosphorylation of NFκB-p65, and sHE4 promotes fibroblastic differentiation and proliferation.
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Yuan Zhan
Jinkun Chen
Jixing Wu
SHILAP Revista de lepidopterología
Respiratory Research
Western University
Huazhong University of Science and Technology
Tongji Hospital
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Zhan et al. (Thu,) studied this question.
www.synapsesocial.com/papers/69d6fc8175cae9790bed8fee — DOI: https://doi.org/10.1186/s12931-022-02040-7