Medium and small HDL particle concentrations were inversely associated with multivessel coronary disease severity (OR 0.77, 95% CI 0.64-0.91 and OR 0.78, 95% CI 0.67-0.91, respectively).
Observational
Are medium and small HDL particle concentrations associated with angiographic coronary heart disease severity in patients with coronary lesions?
In patients with coronary heart disease, higher concentrations of small and medium HDL particles measured by NMR are independently associated with less severe angiographic disease.
Odds Ratio: 0.77 (95% CI 0.64–0.91)
BACKGROUND AND AIMS: The extent of atherosclerotic coronary heart disease (CHD) is associated with its prognosis, thus discovering potential biomarkers related to worse outcomes could prove valuable. The present work aims to investigate whether lipoprotein subfractions are associated with angiographic CHD severity. MATERIALS AND METHODS: Patients from the CORDIOPREV study exhibiting coronary lesions in angiography were classified into two groups (single-vessel coronary disease (SVD) or multivessel coronary disease (MVD)). High-throughput nuclear magnetic resonance (NMR) spectroscopy determined lipoprotein subfractions concentration and composition. RESULTS: SVD patients showed a higher concentration of medium and small HDL particles compared with MVD patients. For medium HDL, total lipids, phospholipids, total cholesterol, cholesteryl esters and free cholesterol reflected HDL particle concentration, whereas, for small HDL, total lipids, phospholipids, and free cholesterol mirrored lipoprotein particle concentration. Among traditional cardiovascular risk factors, age, hypertension and T2D were independently associated with angiography severity. In multivariate logistic regression models, medium and small HDL particles remained inversely associated with angiography severity (OR 0.77 (95% CI: 0.64-0.91); OR 0.78 (95% CI: 0.67-0.91), respectively) after adjusting with covariates. CONCLUSION: In CHD patients mostly on statin treatment, angiography severity is inversely related to small and medium HDL subclasses concentration measured by NMR. These particles are also independent predictors of the presence of MVD, and its use increased the prediction of this entity over traditional risk factors.
Cruz et al. (Sat,) conducted a observational in Coronary heart disease. Medium and small HDL particles concentration vs. Lower concentration was evaluated on Angiography severity (multivessel vs single-vessel coronary disease) (OR 0.77, 95% CI 0.64-0.91). Medium and small HDL particle concentrations were inversely associated with multivessel coronary disease severity (OR 0.77, 95% CI 0.64-0.91 and OR 0.78, 95% CI 0.67-0.91, respectively).
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