Functional mitral regurgitation in type 2 diabetes mellitus patients was associated with a significantly reduced total left atrial emptying fraction of 32.1% compared to 60.0% in age- and sex-matched normal controls.
Cohort (n=148)
No
Does functional mitral regurgitation aggravate left atrial and left ventricular dysfunction in patients with type 2 diabetes mellitus?
Functional mitral regurgitation in patients with type 2 diabetes mellitus is associated with progressive impairment of left atrial and left ventricular function, with regurgitation severity independently determining left atrial reservoir and passive strain.
Effect estimate: null (95% CI null)
Absolute Event Rate: 32.1% vs 60%
p-value: p=<0.05
Abstract Background Functional mitral regurgitation (FMR) in type 2 diabetes mellitus (T2DM) patients induced by left ventricular (LV) enlargement and mitral valve abnormality may aggravated the impairment in left atrial (LA) compliance. Thus, this study aimed to depict how FMR and LV dysfunction affect LA compliance in T2DM patients with FMR. Materials and methods A total of 148 patients with T2DM and 49 age- and sex-matched normal controls underwent cardiac magnetic resonance examination. LA longitudinal strain and LA and LV functional indices were compared among controls and different T2DM patients. The multivariate analysis was used to identify the independent indicators of LA longitudinal strain. Results T2DM Patients without FMR had a lower total LA empty fraction (LAEF) compared with the controls (all P < 0.05). T2DM patients with mild and moderate FMR showed increased LA volume (LAV) and LV volume while decreased LAEF, LA strain, and LV ejection fraction (P < 0.05). T2DM patients with severe FMR showed markedly increased LAV and LV volume while decreased LAEF, LA strain, and LVEF (P < 0.05). In T2DM patients with FMR, reservoir strain (εs) was independently correlated with LV end-diastolic volume (LVEDV) (β = − 0.334) and regurgitation degree (β = − 0.256). The passive strain (εe) was independently correlated with regurgitation degree (β = − 0.297), whereas the active strain (εa) was independently correlated with LVESV (β = − 0.352) and glycated haemoglobin (β = − 0.279). Conclusion FMR may aggravate LA and LV dysfunction in T2DM patients. Regurgitation degree was an independent determinant of the εs and the εe, LVEDV was an independent determinant of the εs, and LVESV was an independent determinant of the εa in T2DM patients with FMR.
Zhang et al. (Thu,) conducted a cohort in Type 2 diabetes mellitus with functional mitral regurgitation (n=148). Functional mitral regurgitation vs. Age- and sex-matched normal controls was evaluated on Total left atrial emptying fraction (LAEF) (null, 95% CI null, p=<0.05). Functional mitral regurgitation in type 2 diabetes mellitus patients was associated with a significantly reduced total left atrial emptying fraction of 32.1% compared to 60.0% in age- and sex-matched normal controls.