Does the arterial pressure-volume index (API) correlate with cardiovascular disease biomarkers in patients with treated hypertension?
The arterial pressure-volume index (API) is a non-invasive marker of arterial stiffness that correlates significantly with established cardiovascular disease biomarkers in hypertensive patients.
Background: The arterial pressure-volume index (API), which is obtained by conventional blood pressure measurement, is a new marker for arterial stiffness. The aim of this study was to clarify the relationships between the API and various clinical parameters, including cardiovascular disease (CVD) biomarkers, in patients with hypertension for the prevention of CVD. Methods: This cross-sectional study enrolled 288 patients with hypertension receiving pharmacological treatment, without a history of CVD (males/females: 115/173; age: 63 ± 11 years (mean ± standard deviation)). The API was automatically calculated using a commercial device. Results: The API was significantly correlated with important CVD biomarkers, such as the concentration of urinary albumin (r = 0.42, P 26 is the optimal cut-off point for determining albuminuria as ≥ 30 mg/g Cr, high high-sensitivity cardiac troponin T concentration as ≥ 0.014 ng/mL, or high skin autofluorescence as ≥ 3.0 arbitrary unit (area under the curve = 0.703, 0.702, and 0.704; and P 26 defines for these biomarkers linked with the formation of CVD.
Takashi Hitsumoto (Wed,) studied this question.