PCSK9 modulated macrophage polarization-mediated ventricular remodeling after myocardial infarction.
Does PCSK9 modulation affect macrophage polarization and ventricular remodeling after acute myocardial infarction?
This preclinical study suggests that PCSK9 plays a role in modulating macrophage polarization and ventricular remodeling after myocardial infarction, providing a potential mechanistic basis for using PCSK9 inhibitors to improve cardiac repair.
Background and Aims: An increasing number of high-risk patients with coronary heart disease (similar to acute myocardial infarction (AMI)) are using PCSK9 inhibitors. However, whether PCSK9 affects myocardial repair and the molecular mechanism of PCSK9 modulation of immune inflammation after AMI are not known. The present research investigated the role of PCSK9 in the immunomodulation of macrophages after AMI and provided evidence for the clinical application of PCSK9 inhibitors after AMI to improve cardiac repair. Methods and Results: B axis was a possible mechanism of PCSK9 regulation of macrophage polarization. Conclusion: Our data suggested that PCSK9 modulated macrophage polarization-mediated ventricular remodeling after myocardial infarction.
Wang et al. (Mon,) conducted a other in Myocardial Infarction. PCSK9 was evaluated on Macrophage polarization-mediated ventricular remodeling. PCSK9 modulated macrophage polarization-mediated ventricular remodeling after myocardial infarction.