Left ventricular global circumferential strain significantly predicted the percentage of replacement fibrosis in patients with hypertrophic cardiomyopathy.
Cross-Sectional (n=51)
No
Does feature-tracking cardiac magnetic resonance predict left ventricular replacement fibrosis in patients with hypertrophic cardiomyopathy?
Non-contrast CMR parameters, specifically LV GCS and LV EDVI, can serve as valuable markers for predicting replacement fibrosis in patients with hypertrophic cardiomyopathy.
Effect estimate: Coefficient 3.49 (95% CI 1.48-5.50)
p-value: p=0.001
Purpose Left ventricular (LV) replacement fibrosis is a marker of adverse cardiac events in hypertrophic cardiomyopathy (HCM). We aimed to assess the efficacy of the feature-tracking cardiac magnetic resonance (FT-CMR) in the detection of LV replacement fibrosis. Material and methods Fifty-one patients with HCM (51% female, mean age = 21 ± 5.2 years) and significant myocardial hypertrophy, who underwent CMR between February 2018 and December 2019 were enrolled. Functional and 3D FT-CMR parameters were measured. LV global longitudinal strain, global radial strain (GRS), and global circumferential strain (GCS) were recorded. The percentage of enhanced myocardial mass was calculated. Univariate and multivariate regression analyses were performed to determine the predictors of fibrosis. A p-value of less than 0.05 was considered significant. Results The mean enhanced mass percentage was 15.2 ± 10.53%. Among LV volumetric parameters, end-systolic and end-diastolic volume indices predicted fibrosis (fitness F = 8.11 and p = 0.006 vs. F = 6.6 and p = 0.012, correspondingly). The univariate linear regression demonstrated that GCS and GRS predicted total enhanced mass (%) (F = 12.29 and p = 0.001 vs. F = 7.92 and p = 0.007, respectively). After the inclusion of all volumetric and deformation parameters, the multivariate analysis identified the model of a combination of LV end-diastolic volume index (LV EDVI) and LV GCS as a robust predictor of the fibrosis percentage (F = 8.86 and p = 0.005). Conclusions Non-contrast CMR parameters including LV GCS and LV EDVI are valuable markers of replacement fibrosis in HCM patients with notable myocardial hypertrophy.
Rezaeian et al. (Mon,) conducted a cross-sectional in Hypertrophic cardiomyopathy (n=51). Feature-tracking cardiac magnetic resonance was evaluated on Prediction of total enhanced mass (%) by global circumferential strain (Coefficient 3.49, 95% CI 1.48-5.50, p=0.001). Left ventricular global circumferential strain significantly predicted the percentage of replacement fibrosis in patients with hypertrophic cardiomyopathy.