Women with type A acute aortic dissection have higher overall in-hospital mortality and undergo less frequent surgical treatment than men, while no significant mortality difference exists in type B.
What are the gender differences in the epidemiology, clinical presentation, management, and outcomes of acute aortic dissection?
Women with acute aortic dissection present later, with atypical symptoms, and experience higher in-hospital mortality in type A AAD compared to men, highlighting the need for gender-specific strategies.
Cardiovascular disease (CVD) represents the most important cause of mortality and morbidity worldwide. There is heterogeneity in the epidemiology and management of CVD between male and female patients. In the specific case of acute aortic dissection (AAD), women, at the time of diagnosis, are older than men and complain less frequently of an abrupt onset of pain with delayed presentation to the emergency department. Furthermore, a history of hypertension and chronic obstructive pulmonary disease is more common among women. In type A AAD, women more often experience pleural effusion and coronary artery compromise, but experience less neurological and malperfusion symptoms. They undergo less frequent surgical treatment and have higher overall in-hospital mortality. Conversely, in type B AAD no significant differences were shown for in-hospital mortality between the two genders. However, it should be highlighted that further studies are needed in order to develop AAD gender specific preventive, diagnostic and therapeutic strategies.
Bossone et al. (Fri,) conducted a review in Acute Aortic Dissection. Female gender vs. Male gender was evaluated on In-hospital mortality. Women with type A acute aortic dissection have higher overall in-hospital mortality and undergo less frequent surgical treatment than men, while no significant mortality difference exists in type B.
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