Implantable loop recorder screening reduced the risk of stroke or systemic arterial embolism by 44% among participants with systolic blood pressure ≥150 mm Hg (HR 0.56; 95% CI 0.37-0.83).
RCT (n=5,997)
Does screening with an implantable loop recorder reduce stroke or systemic arterial embolism in AF-naïve older adults with stroke risk factors, and does baseline systolic blood pressure modify this effect?
Screening for atrial fibrillation with an implantable loop recorder significantly reduces the risk of stroke or systemic arterial embolism specifically in older adults with systolic blood pressure ≥150 mm Hg.
Effect estimate: HR 0.56 (95% CI 0.37-0.83)
Background: Hypertension is a well-known risk factor for atrial fibrillation (AF) and stoke, but data on the interaction between systolic blood pressure (SBP) and effects of AF screening are lacking. Methods: The LOOP Study randomized AF-naïve individuals aged 70 to 90 years with additional stroke risk factors to either screening with implantable loop recorder (ILR) and anticoagulation initiation upon detection of AF episodes ≥6 minutes, or usual care. In total, 5997 participants with available baseline SBP measurements were included in this substudy. Outcomes were analyzed according to the time-to-first-event principle using cause-specific Cox models. Results: The hazard ratio of stroke or systemic arterial embolism for ILR versus control decreased with increasing SBP. ILR screening yielded a 44% risk reduction of stroke or systemic arterial embolism among participants with SBP ≥150 mm Hg (adjusted hazard ratio, 0.56 0.37–0.83). Within the ILR group, SBP≥150 mm Hg was associated with a higher incidence of AF episodes ≥24 hours than lower SBP (adjusted hazard ratio, 1.70 1.08–2.69) but not with the overall occurrence of AF (adjusted P >0.05). Conclusions: The impact of AF screening on thromboembolic events increased with increasing blood pressure. SBP≥150 mm Hg was associated with a >1.5-fold increased risk of AF episodes ≥24 hours, along with an almost 50% risk reduction of stroke or systemic arterial embolism by ILR screening compared to lower blood pressure. These findings should be considered hypothesis-generating and warrant further study. Registration: URL: https://www.clinicaltrials.gov ; Unique Identifier: NCT02036450.
Xing et al. (Wed,) conducted a rct in Atrial fibrillation screening (n=5,997). Implantable loop recorder (ILR) screening vs. Usual care was evaluated on Stroke or systemic arterial embolism (HR 0.56, 95% CI 0.37-0.83). Implantable loop recorder screening reduced the risk of stroke or systemic arterial embolism by 44% among participants with systolic blood pressure ≥150 mm Hg (HR 0.56; 95% CI 0.37-0.83).