Omega-3 fatty acid supplementation was associated with a lower risk of major cardiovascular events (RR 0.94; 95% CI 0.89-1.00; P=.049) and cardiac death, but not all-cause mortality.
Meta-Analysis (n=136,965)
Does omega-3 fatty acid supplementation reduce major cardiovascular outcomes in individuals for primary and secondary prevention?
Omega-3 fatty acid supplementation is associated with a modest reduction in major cardiovascular events and cardiac death, but not all-cause mortality, MI, or stroke.
Effect estimate: RR 0.94 (95% CI 0.89-1.00)
p-value: p=.049
BACKGROUND: The effects of omega-3 fatty acid on cardiovascular health obtained inconsistent results. A systematic review and meta-analysis were therefore conducted to assess the effects of omega-3 fatty acid supplementation for primary and secondary prevention strategies of major cardiovascular outcomes. METHODS: The databases of PubMed, Embase, and the Cochrane library were systematically searched from their inception until September 2020. Relative risks (RRs) with 95% confidence intervals were used to assess effect estimates by using the random-effects model. RESULTS: Twenty-eight randomized controlled trials involving 136,965 individuals were selected for the final meta-analysis. Omega-3 fatty acid was noted to be associated with a lower risk of major cardiovascular events (RR, 0.94; 95% CI, 0.89-1.00; P = .049) and cardiac death (RR, 0.92; 95% CI, 0.85-0.99; P = .022). However, no significant differences was noted between omega-3 fatty acid and the control for the risks of all-cause mortality (RR, 0.97; 95% CI, 0.92-1.03; P = .301), myocardial infarction (RR, 0.90; 95% CI, 0.80-1.01; P = .077), and stroke (RR, 1.02; 95% CI, 0.94-1.11; P = .694). CONCLUSIONS: Major cardiovascular events and cardiac death risks could be avoided with the use of omega-3 fatty acid. However, it has no significant effects on the risk of all-cause mortality, myocardial infarction, and stroke.
Yu et al. (Fri,) conducted a meta-analysis in Primary and secondary prevention of major cardiovascular outcomes (n=136,965). Omega-3 fatty acid vs. Control was evaluated on Major cardiovascular events (RR 0.94, 95% CI 0.89-1.00, p=.049). Omega-3 fatty acid supplementation was associated with a lower risk of major cardiovascular events (RR 0.94; 95% CI 0.89-1.00; P=.049) and cardiac death, but not all-cause mortality.