Youth with type 1 diabetes and early microvascular complications (n=20) had significantly higher carotid intima-media thickness, which correlated positively with HbA1c, hsCRP, and NT-pro-BNP.
Observational (n=72)
Are inflammation and oxidative stress biomarkers associated with increased carotid IMT in youth with type 1 diabetes and early microvascular complications?
Youth with type 1 diabetes and early microvascular complications exhibit increased carotid IMT and altered biomarkers (hsCRP, MPO, NT-proBNP), suggesting an increased risk of macroangiopathy and early myocardial injury.
Recent years have confirmed the importance of oxidative stress and biomarkers of inflammation in estimating the risk of cardiovascular disease (CVD) and explaining not fully understood pathogenesis of diabetic macroangiopathy. We aimed to analyze the relation between the intima-media thickness (IMT) of common carotid arteries and the occurrence of classical cardiovascular risk factors, together with the newly proposed biomarkers of CVD risk (high-sensitivity C-reactive protein (hsCRP), myeloperoxidase (MPO), adiponectin, N-terminal-pro B-type natriuretic peptide (NT-proBNP) and vitamin D) in youth with type 1 diabetes (T1D) recognized in screening tests to present early stages of microvascular complications (VC). The study group consisted of 50 adolescents and young adults with T1D, mean age 17.1 years (10-26 age range), including 20 patients with VC (+) and 30 VC (-). The control group (Control) consisted of 22 healthy volunteers, mean age 16.5 years (11-26 age range). In the VC (+) patients, we found a significantly higher concentration of HbA1c, lipid levels, hsCRP and NT-proBNP. BMI and blood pressure values were highest in the VC (+) group. Higher levels of MPO and lower levels of vitamin D were found in both diabetic groups vs. Control. IMT in VC (+) patients was significantly higher and correlated positively with HbA1c, hsCRP, NT-pro-BNP and negatively with vitamin D levels. In conclusion, youth with T1D and VC (+) present many abnormalities in the classical and new CVD biomarkers. hsCRP and MPO seem to be the most important markers for estimating the risk of macroangiopathy. NT-proBNP may present a possible marker of early myocardial injury in this population.
Peczyńska et al. (Sat,) conducted a observational in Type 1 Diabetes with early microvascular complications (n=72). Type 1 diabetes with early microvascular complications (VC+) vs. Type 1 diabetes without microvascular complications (VC-) and healthy controls was evaluated on Carotid intima-media thickness (IMT) and cardiovascular biomarkers (hsCRP, MPO, adiponectin, NT-proBNP, vitamin D). Youth with type 1 diabetes and early microvascular complications (n=20) had significantly higher carotid intima-media thickness, which correlated positively with HbA1c, hsCRP, and NT-pro-BNP.
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