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Systemic lupus erythematosus has many guises, but the unifying feature is the presence of antibodies against double-stranded DNA in almost all patients. This review provides data that show that such autoantibodies cause the renal lesions of systemic lupus erythematosus, and it emphasizes the importance of histones, histone fragments, and other nuclear autoantigens.
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Anisur Rahman
Greater Manchester Mental Health NHS Foundation Trust
David Isenberg
Northwestern University
New England Journal of Medicine
University College London
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Rahman et al. (Wed,) studied this question.
synapsesocial.com/papers/69ff76f5831589f3542d8f33 — DOI: https://doi.org/10.1056/nejmra071297