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An engineered AmDH derived from a leucine dehydrogenase was used as the starting enzyme to improve its activity in the synthesis of ( R )-3-amino-1-butanol. Preparative-scale synthesis of the ( R )-product (90% yield, >99%) was performed on a gram-scale.
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Hui Ming
Bo Yuan
Ge Qu
Catalysis Science & Technology
Chinese Academy of Sciences
University of Science and Technology of China
Tianjin Institute of Industrial Biotechnology
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Ming et al. (Sat,) studied this question.
www.synapsesocial.com/papers/69d73cf852964041bdf306e7 — DOI: https://doi.org/10.1039/d2cy00391k
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