Greater large artery stiffness, assessed via prospective cohort data and Mendelian randomization, was associated with an increased risk of developing type 2 diabetes (P=0.049).
Cohort (n=5,676)
Yes
Is greater large artery stiffness associated with an increased risk of developing type 2 diabetes in patients without baseline diabetes?
Greater large artery stiffness is associated with an increased risk of developing type 2 diabetes, suggesting it may serve as a useful marker for future diabetes risk.
p-value: p==0.049
BACKGROUND: Microvascular damage from large artery stiffness (LAS) in pancreatic, hepatic, and skeletal muscles may affect glucose homeostasis. Our goal was to evaluate the association between LAS and the risk of type 2 diabetes using prospectively collected, carefully phenotyped measurements of LAS as well as Mendelian randomization analyses. METHODS: Carotid-femoral pulse wave velocity (CF-PWV) and brachial and central pulse pressure were measured in 5676 participants of the FHS (Framingham Heart Study) without diabetes. We used Cox proportional hazards regression to evaluate the association of CF-PWV and pulse pressure with incident diabetes. We subsequently performed 2-sample Mendelian randomization analyses evaluating the associations of genetically predicted brachial pulse pressure with type 2 diabetes in the UKBB (United Kingdom Biobank). RESULTS: =0.049). CONCLUSIONS: Using prospective cohort data coupled with Mendelian randomization analyses, we found evidence supporting that greater LAS is associated with increased risk of developing diabetes. LAS may play an important role in glucose homeostasis and may serve as a useful marker of future diabetes risk.
Cohen et al. (Wed,) conducted a cohort in Type 2 diabetes (n=5,676). Large artery stiffness (CF-PWV and pulse pressure) was evaluated on Incident type 2 diabetes (p==0.049). Greater large artery stiffness, assessed via prospective cohort data and Mendelian randomization, was associated with an increased risk of developing type 2 diabetes (P=0.049).