Daily percutaneous electrical muscle stimulation-induced muscle contraction during hindlimb unloading rescued the reduction in ribosome synthesis-related proteins and ribosome content in mice.
Does daily percutaneous electrical muscle stimulation prevent the decrease in ribosome synthesis and content in a mouse model of hindlimb unloading?
Percutaneous electrical muscle stimulation can mitigate muscle atrophy mechanisms by preserving ribosome synthesis and content during unloading in a preclinical model.
Muscle inactivity reduces ribosome synthesis and content during atrophy. Whether percutaneous electrical muscle stimulation (pEMS)-induced muscle contraction rescues the ribosome synthesis and content during muscle unloading is unclear. Using a mouse hindlimb-unloading model with pelvic suspension, we provide evidence that daily pEMS-induced muscle contraction during hindlimb unloading rescues the reduction in the expression of some ribosome synthesis-related proteins and ribosome content in the gastrocnemius muscle.
Kotani et al. (Fri,) conducted a other in Muscle atrophy. Percutaneous electrical muscle stimulation (pEMS) vs. Hindlimb unloading without pEMS was evaluated on Expression of ribosome synthesis-related proteins and ribosome content in the gastrocnemius muscle. Daily percutaneous electrical muscle stimulation-induced muscle contraction during hindlimb unloading rescued the reduction in ribosome synthesis-related proteins and ribosome content in mice.