What is the incidence of sudden cardiac death and life-threatening arrhythmias in patients with clinically manifest cardiac sarcoidosis without current ICD indications?
Patients with clinically manifest cardiac sarcoidosis have a clinically significant 5-year risk of sudden cardiac death even without current guideline indications for an ICD, suggesting broader consideration for ICD implantation.
Current ICD guidelines fail to distinguish a truly low-risk group of patients with clinically manifest CS, the 5-year risk of SCD approaching 5% despite absent ICD indications. Further research is needed on prognostic factors, including the role of diagnostic histology. Meanwhile, all patients with CS presenting with clinical cardiac manifestations should be considered for an ICD implantation.
Nordenswan et al. (Mon,) studied this question.