Does a modified anaesthetic protocol improve animal survival and alter the characteristics of ventricular arrhythmias in a domestic pig model of acute myocardial infarction?
A modified anaesthetic protocol in a porcine model of acute myocardial infarction yields high survival rates, making it a viable and ethical model for studying ischaemic ventricular arrhythmias.
Myocardial infarction due to proximal LAD occlusion is characterised by a high incidence of ventricular arrhythmias, especially VT and VF. Because of the high survival rate, this MI porcine model may serve as a model for research on acute ischaemic ventricular arrhythmias in humans. Additionally, it reduces the total number of animals required for testing while yielding meaningful results, which is in line with the 3R principle.
Frydrychowski et al. (Mon,) studied this question.
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