A quantitative review of 73 published mammalian models of the cardiac L-type calcium current revealed large variability in their predictions that is not diminished by grouping by species.
This review demonstrates significant variability among existing computational models of the cardiac L-type calcium current, highlighting the need for a community consensus model.
Abstract The L‐type calcium current () plays a critical role in cardiac electrophysiology, and models of are vital tools to predict arrhythmogenicity of drugs and mutations. Five decades of measuring and modeling have resulted in several competing theories (encoded in mathematical equations). However, the introduction of new models has not typically been accompanied by a data‐driven critical comparison with previous work, so that it is unclear which model is best suited for any particular application. In this review, we describe and compare 73 published mammalian models and use simulated experiments to show that there is a large variability in their predictions, which is not substantially diminished when grouping by species or other categories. We provide model code for 60 models, list major data sources, and discuss experimental and modeling work that will be required to reduce this huge list of competing theories and ultimately develop a community consensus model of . This article is categorized under: Cardiovascular Diseases > Computational Models Cardiovascular Diseases > Molecular and Cellular Physiology
Agrawal et al. (Fri,) conducted a review in Cardiac electrophysiology (L-type calcium current). Mathematical models of the cardiac L-type calcium current was evaluated on Variability in model predictions. A quantitative review of 73 published mammalian models of the cardiac L-type calcium current revealed large variability in their predictions that is not diminished by grouping by species.