A genetic risk score for NT-proBNP increased plasma levels by 1.13-fold per additional effect allele, with the genetic effect being significantly stronger in individuals with higher household income.
Cross-Sectional (n=4,520)
Yes
4,520 adults aged 45 to 75 years from a population-based cohort in Germany, assessed cross-sectionally to evaluate the interaction between genetic variants and socioeconomic factors on NT-proBNP levels.
Genetic risk allele sum score (GRSNT-proBNP) vs Fewer effect alleles
Log-transformed NT-proBNP plasma levels — Exp(β) 1.13 (1.10-1.16), p=3.8 × 10-21
Effect estimate: Exp(β) 1.13 (95% CI 1.10-1.16)
p-value: p=3.8 × 10-21
Abstract N-terminal prohormone of brain natriuretic peptide (NT-proBNP) is an established biomarker for diagnosis of heart failure. The study aims to explore whether known cardiovascular risk factors, including education and income as indicators of socioeconomic position (SEP), may interact with the genetic effect of NT-proBNP-related single nucleotide polymorphisms (SNP) to influence plasma levels of NT-proBNP in a population-based study sample. Information on effect alleles of three SNPs previously reported to be related to NT-proBNP was combined individually for 4,520 participants of the Heinz Nixdorf Recall Study to calculate a genetic risk allele sum score (GRS NT-proBNP ). Linear Regression models were used to examine the association of cardiovascular risk factors and GRS NT-proBNP with log-transformed NT-proBNP levels, as well as cardiovascular risk factor by GRS NT-proBNP interactions. The GRS NT-proBNP was associated with NT-proBNP showing 1.13-fold (95% CI 1.10–1.16) higher plasma levels per additional effect allele. Interaction terms included in the regression models gave some indication for interaction of the GRS NT-proBNP with the SEP indicator income as well as with C-reactive protein. In regression models stratified by income quartiles the strongest genetic effect was observed in the third income quartile showing 1.18-fold (95% CI 1.12–1.25) higher average NT-proBNP levels per additional allele compared to the lowest income quartile with 1.08-fold (95% CI 1.01–1.15) higher NT-proBNP levels. The results of the present study indicate that genetic effects of NT-proBNP increasing alleles are stronger in higher SEP groups. This may be due to a stronger influence of non-genetic cardiovascular risk on NT-proBNP in low SEP groups.
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Emanuel Matusch
University of Duisburg-Essen
Mirjam Frank
University of Duisburg-Essen
Kaffer Kara
Ruhr University Bochum
Scientific Reports
Heinrich Heine University Düsseldorf
University of Duisburg-Essen
Düsseldorf University Hospital
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Matusch et al. (Fri,) conducted a cross-sectional in General population (n=4,520). Genetic risk allele sum score (GRSNT-proBNP) vs. Fewer effect alleles was evaluated on Log-transformed NT-proBNP plasma levels (Exp(β) 1.13, 95% CI 1.10-1.16, p=3.8 × 10-21). A genetic risk score for NT-proBNP increased plasma levels by 1.13-fold per additional effect allele, with the genetic effect being significantly stronger in individuals with higher household income.
synapsesocial.com/papers/6a20e886e2d1a39857ecc3fc — DOI: https://doi.org/10.1038/s41598-022-19821-1