BAV patients with non-dilated ascending aortas exhibit underlying structural abnormalities, including vascular smooth muscle cell differentiation defects and a thinner intimal layer.
The BAV ascending aorta without dilatation is characterized by a differentiation defect of vascular smooth muscle cells in the media and a significantly thinner intimal layer without overt pathologic features.
Grewal et al. (Fri,) studied this question.
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