Over 6 months of recovery from mild SARS-CoV-2 infection, basal systolic (p=0.019) and diastolic (p<0.001) blood pressure decreased, with no significant changes in basal sympathetic nerve activity.
Cohort
How do sympathetic neural activity and hemodynamics change over 6 months of recovery from SARS-CoV-2 infection in young adults?
Blood pressure improves over 6 months of recovery from mild SARS-CoV-2 infection, but this improvement is likely not a direct result of changes in sympathetic activity.
p-value: p=0.019 for SBP, p<0.001 for DBP
Cross-sectional data indicate that acute SARS-CoV-2 infection increases resting muscle sympathetic nerve activity (MSNA) and alters hemodynamic responses to orthostasis in young adults. However, the longitudinal impact of contracting SARS-CoV-2 on autonomic function remains unclear. The aim of this study was to longitudinally track MSNA, sympathetic transduction to blood pressure (BP), and hemodynamics over 6 months following SARS-CoV-2 infection. Young adults positive with SARS-CoV-2 reported to the laboratory three times over 6 months (V1:41 ± 17, V2:108 ± 21, V3:173 ± 16 days post-infection). MSNA, systolic (SBP) and diastolic (DBP) blood pressure, and heart rate (HR) were measured at rest, during a cold pressor test (CPT), and at 30° head-up tilt (HUT). Basal SBP (p = 0.019) and DBP (p < 0.001) decreased throughout the 6 months, whereas basal MSNA and HR were not different. Basal sympathetic transduction to BP and estimates of baroreflex sensitivity did not change over time. SBP and DBP were lower during CPT (SBP: p = 0.016, DBP: p = 0.007) and HUT at V3 compared with V1 (SBP: p = 0.041, DBP: p = 0.017), with largely no changes in MSNA. There was a trend toward a visit-by-time interaction for burst incidence (p = 0.055) during HUT, wherein at baseline immediately prior to tilting, burst incidence was lower at V3 compared with V1 (p = 0.014), but there were no differences between visits in the 30 HUT position. These results support impairments to cardiovascular health, and potentially autonomic function, which may improve over time. However, the improvements in BP over 6 months recovery from mild SARS-CoV-2 infection are likely not a direct result of changes in sympathetic activity.
Stute et al. (Thu,) conducted a cohort in SARS-CoV-2 infection. Time post-SARS-CoV-2 infection vs. Baseline (V1, ~41 days post-infection) was evaluated on Basal systolic and diastolic blood pressure over 6 months (p=p=0.019 for SBP, p<0.001 for DBP). Over 6 months of recovery from mild SARS-CoV-2 infection, basal systolic (p=0.019) and diastolic (p<0.001) blood pressure decreased, with no significant changes in basal sympathetic nerve activity.