Frailty in older patients with AMI after PCI has a prevalence of 39% and is associated with increased all-cause mortality (HR 2.29; 95% CI 1.65-3.16).
Meta-Analysis (n=274,976)
Does frailty increase the risk of adverse outcomes in older patients with acute myocardial infarction after percutaneous coronary intervention?
Frailty is highly prevalent (39%) in older patients with AMI undergoing PCI and is associated with significantly increased risks of mortality, rehospitalization, and major bleeding.
Effect estimate: HR 2.29 (95% CI 1.65-3.16)
p-value: p=.285
BACKGROUND: The association between frailty and older patients with acute myocardial infarction (AMI) after percutaneous coronary intervention (PCI) is unclear. Therefore, we conducted a systematic review and meta-analysis to investigate the prevalence of frailty in older patients with AMI following PCI, and determine the relationship between frailty and adverse outcomes in these patients. HYPOTHESIS: Older patients with AMI have a higher prevalence of frailty after PCI, and the frailty in these patients increases the risk of adverse outcomes. METHODS: was greater than 50%; otherwise, a fixed-effects model was used. RESULTS: There were a total of 274,976 older patients in the included studies. Nine studies investigated the prevalence of frailty in older patients with AMI after PCI, with an overall prevalence of 39% (95% confidence interval CI: 18%-60%, p < .001). Six studies included adverse outcomes of frailty in older patients with AMI after PCI, including all-cause mortality (hazard ratio HR = 2.29, 95% CI: 1.65-3.16, p = .285), rehospitalization (HR = 2.53, 95% CI: 1.38-4.63), and in-hospital major bleeding (HR = 1.93, 95% CI: 1.29-2.90, p = .825). CONCLUSION: The frailty prevalence is increased in older patients with AMI after PCI, especially in ST-segment elevation myocardial infarction (STEMI). AMI with frailty after PCI is more likely to be associated with worse clinical outcomes, such as death, bleeding, and rehospitalization.
Yu et al. (Wed,) conducted a meta-analysis in Acute myocardial infarction (AMI) after percutaneous coronary intervention (PCI) (n=274,976). Frailty was evaluated on All-cause mortality (HR 2.29, 95% CI 1.65-3.16, p=.285). Frailty in older patients with AMI after PCI has a prevalence of 39% and is associated with increased all-cause mortality (HR 2.29; 95% CI 1.65-3.16).