An E' cutoff >7.2 cm/s on pulsed tissue Doppler imaging discriminated normal from hypertrophic cardiomyopathy cats with 92% sensitivity and 87% specificity.
Case-Control (n=48)
Does pulsed tissue Doppler imaging detect differences in myocardial motion between normal cats and cats with hypertrophic cardiomyopathy?
Pulsed tissue Doppler imaging effectively identifies both diastolic and systolic impairment in cats with HCM, demonstrating the loss of normal physiologic nonhomogeneity in myocardial motion.
Abstract Myocardial motion was quantified in normal cats (n = 25) and cats with hypertrophic cardiomyopathy (HCM) (n = 23) using the pulsed tissue Doppler imaging (TDI) technique. A physiologic nonuniformity was documented in the myocardial motion of normal cats, which was detected as higher early diastolic velocities, acceleration, and deceleration in the interventricular septum compared with the left ventricular free wall (LVFW). HCM cats exhibited lower early diastolic velocities, acceleration, and deceleration and also prolonged isovolumic relaxation time compared with normal cats. These differences were detected mainly along the longitudinal axis of the heart. A cutoff value of E' in the LVFW along the longitudinal axis 7.2 cm/s discriminated normal from HCM cats with a sensitivity of 92% and a specificity of 87%. The physiologic nonuniformity of myocardial motion during diastole was lost in affected cats. Systolic impairment (decreased late-systolic velocities in most segments along the longitudinal axis and decreased early systolic acceleration in both mitral annular sites) was evident in HCM cats irrespective of the presence of left ventricular outflow tract obstruction and congestive heart failure. Postsystolic thickening was recorded in the LVFW along the longitudinal axis only in affected cats (n = 6) and was another finding indicative of systolic impairment in the HCM of this species. This study identified both diastolic and systolic impairment in cats with HCM compared with normal cats. The study also documents the normal physiologic nonhomogeneity in myocardial motion in cats and the subsequent loss of this feature in the HCM diseased state.
Koffas et al. (Sun,) conducted a case-control in Hypertrophic cardiomyopathy (n=48). Hypertrophic cardiomyopathy vs. Normal cats was evaluated on Myocardial motion parameters including early diastolic velocities, acceleration, and deceleration. An E' cutoff >7.2 cm/s on pulsed tissue Doppler imaging discriminated normal from hypertrophic cardiomyopathy cats with 92% sensitivity and 87% specificity.