Can inflammatory and endothelial markers predict cardiovascular adaptations in ultra-marathon runners?
Inflammatory and endothelial markers such as ADMA and TNF-α can predict structural cardiovascular adaptations like abnormal LV diameter and mass in ultra-marathon runners.
) had higher IL-6 values compared with runners with a normal LAVI (1.09+0.19 vs. 0.99±0.08 pg/ml, P<0.05). ROC curves analysis revealed that ADMA values were able to predict an abnormal LV diameter detected by echocardiography P<0.05; area under the curve (AUC), 0.763, while TNF-α values could predict an abnormal LV mass in marathon runners (P<0.05; AUC, 0.78). On the whole, the present study demonstrates that, in ultra-marathon runners, cardiovascular adaptations to running are characterized by a specific pattern of changes in inflammatory and endothelial markers, which in turn can be used to predict the occurrence of the observed adaptations.
Tsarouhas et al. (Thu,) studied this question.
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