Radical Nephrectomy for Renal Cell Carcinoma 30 MM. or Less: Long-Term Followup Results

No AccessJournal of UrologyClinical Urology: Original Article1 Apr 1996Radical Nephrectomy for Renal Cell Carcinoma 30 MM. or Less: Long-Term Followup Results P. Eschwege, C. Saussine, G. Steichen, B. Delepaul, L. Drelon, and D. Jacqmin P. EschwegeP. Eschwege More articles by this author , C. SaussineC. Saussine More articles by this author , G. SteichenG. Steichen More articles by this author , B. DelepaulB. Delepaul More articles by this author , L. DrelonL. Drelon More articles by this author , and D. JacqminD. Jacqmin More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)66213-XAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: We investigated the clinical and pathological features, and long-term followup of patients treated with radical nephrectomy for renal cell carcinoma of 30 mm. or smaller and a normal contralateral kidney. Materials and Methods: Between 1973 and 1993, 74 patients 29 to 83 years old (average age 60) underwent radical nephrectomy for renal cell carcinoma of 30 mm. or smaller. Average followup was 101 months (range 10 to 236). Of the 74 tumors 21 were stage pT1, 36 stage pT2 and 12 stage pT3 (all 69 stage NO to NxMO), while 5 were stages pT1 to 3, N1 or M1. A total of 27 patients died during followup. Of 11 patients who died of disease progression 5 had metastatic disease initially. Results: Overall survival rates were 73 percent at 5 years, 55 percent at 10 years and 38 percent at 20 years. Cancer-specific survival rates without the 5 patients with stage N1 or M1 disease were 91 percent at 5 years, and 80 percent at 10 and 20 years. For the group with nonmultifocal renal cell carcinoma, stage NO to Nx and/or MO, the cancer-specific survival rates were 93 percent at 5 years, and 81 percent at 10 and 20 years. For the group with multifocal renal cell carcinoma, stage NO to Nx and/or MO, the cancer-specific survival rate was 75 percent at 5, 10 and 20 years. There was a significant survival difference between the nonmultifocal and multifocal renal cell carcinoma groups at 5 years (p less than 0.05) but not at 10 and 20 years. Conclusions: Small renal cell carcinoma is definitively not a benign disease and a tumor of 30 mm. or smaller does not mean there is no risk of metastatic or multifocal disease. References 1 : Renal cell carcinoma: earlier discovery and increased detection. Radiology1989; 170: 699. Google Scholar 2 : The results of radical nephrectomy for renal cell carcinoma. J. Urol.1969; 101: 297. Link, Google Scholar 3 : Nephron sparing surgery for renal cell carcinoma. J. Urol.1993; 149: 1. Link, Google Scholar 4 : The incidence of multicentricity in renal cell carcinoma. J. Urol.1991; 146: 1221. 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Google Scholar Service de Chirurgie Urologique, Pavillon Chirurgical A, Hopitaux Universitaires de Strasbourg, Strasbourg, Cedex, France© 1996 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byLughezzani G, Jeldres C, Isbarn H, Perrotte P, Shariat S, Sun M, Widmer H, Arjane P, Peloquin F, Pharand D, Patard J, Graefen M, Montorsi F and Karakiewicz P (2018) Tumor Size is a Determinant of the Rate of Stage T1 Renal Cell Cancer Synchronous MetastasisJournal of Urology, VOL. 182, NO. 4, (1287-1293), Online publication date: 1-Oct-2009.RICHSTONE L, SCHERR D, REUTER V, SNYDER M, RABBANI F, KATTAN M and RUSSO P (2018) Multifocal Renal Cortical Tumors: Frequency, Associated Clinicopathological Features and Impact on SurvivalJournal of Urology, VOL. 171, NO. 2, (615-620), Online publication date: 1-Feb-2004.DUFFEY B, CHOYKE P, GLENN G, GRUBB R, VENZON D, LINEHAN W and WALTHER M (2018) THE RELATIONSHIP BETWEEN RENAL TUMOR SIZE AND METASTASES IN PATIENTS WITH VON HIPPEL-LINDAU DISEASEJournal of Urology, VOL. 172, NO. 1, (63-65), Online publication date: 1-Jul-2004.BÖHM M, ITTENSON A, PHILIPP C, RÖHL F, ANSORGE S and ALLHOFF E (2018) COMPLEX PERIOPERATIVE IMMUNO-DYSFUNCTION IN PATIENTS WITH RENAL CELL CARCINOMAJournal of Urology, VOL. 166, NO. 3, (831-836), Online publication date: 1-Sep-2001.ONO Y, KINUKAWA T, HATTORI R, GOTOH M, KAMIHIRA O and OHSHIMA S (2018) THE LONG-TERM OUTCOME OF LAPAROSCOPIC RADICAL NEPHRECTOMY FOR SMALL RENAL CELL CARCINOMAJournal of Urology, VOL. 165, NO. 6 Part 1, (1867-1870), Online publication date: 1-Jun-2001.WALTHER M, CHOYKE P, GLENN G, LYNE J, RAYFORD W, VENZON D and LINEHAN W (2018) RENAL CANCER IN FAMILIES WITH HEREDITARY RENAL CANCER: PROSPECTIVE ANALYSIS OF A TUMOR SIZE THRESHOLD FOR RENAL PARENCHYMAL SPARING SURGERYJournal of Urology, VOL. 161, NO. 5, (1475-1479), Online publication date: 1-May-1999.Nativ O, Sabo E, Raviv G, Madjar S, Halachmi S and Moskovitz B (2018) The Impact of Tumor Size on Clinical Outcome in Patients With Localized Renal Cell Carcinoma Treated by Radical NephrectomyJournal of Urology, VOL. 158, NO. 3, (729-732), Online publication date: 1-Sep-1997. Volume 155Issue 4April 1996Page: 1196-1199 Advertisement Copyright & Permissions© 1996 by American Urological Association, Inc.MetricsAuthor Information P. Eschwege More articles by this author C. Saussine More articles by this author G. Steichen More articles by this author B. Delepaul More articles by this author L. Drelon More articles by this author D. Jacqmin More articles by this author Expand All Advertisement PDF downloadLoading ...