The Notch signaling pathway serves as a potential therapeutic target for improving cardiac recovery after myocardial infarction through its cardioprotective effects.
The Notch signaling pathway represents a potential therapeutic target for improving cardiac recovery and preventing heart failure after myocardial infarction.
Myocardial infarction (MI) is a pathological process, evidencing as massive death of cardiomyocytes associated with hypoxic and oxidative stress. The formation of areas of fibrosis ultimately leads to heart failure. There are some mechanisms that contribute to the functional repair of the heart. In most mammals, including humans, the Notch signaling pathway has cardioprotective effects. It is involved in the formation of the heart in embryogenesis and in the restoration of cardiac function after MI due to: (1) reducing oxidative stress; (2) prevention of apoptosis; (3) regulation of inflammation; (4) containment of fibrosis and hypertrophy of cardiomyocytes; (5) tissue revascularization; and (6) regulation of proliferation and differentiation of cardiomyocytes. In addition, the Notch signaling pathway interacts with other signaling cascades involved in the pathogenesis of MI and subsequent cardiac repair. In this review, we consider the Notch signaling pathway as a potential target for therapeutic approaches aimed at improving cardiac recovery after MI.
Kachanova et al. (Wed,) conducted a review in Myocardial infarction. Notch signaling pathway targeting was evaluated. The Notch signaling pathway serves as a potential therapeutic target for improving cardiac recovery after myocardial infarction through its cardioprotective effects.