Hypertrophic cardiomyopathy was significantly associated with an increased risk of incident mental disorders compared to matched controls (HR 1.719; 95% CI 1.589-1.860).
Cohort (n=16,184)
Yes
Does hypertrophic cardiomyopathy increase the risk of incident mental disorders compared to matched controls?
Hypertrophic cardiomyopathy is significantly associated with an increased risk of incident mental disorders, particularly within the first year after diagnosis.
Effect estimate: HR 1.719 (95% CI 1.589-1.860)
Absolute Event Rate: 54.4% vs 31.5%
AIMS: We sought to determine the risk of mental disorders in patients with hypertrophic cardiomyopathy (HCM) compared with those without HCM. METHODS AND RESULTS: This is a retrospective propensity score-matched cohort study using nationwide population-based data from the Korean National Health Insurance Service. Overall, 4046 patients with HCM and 12138 matched individuals were followed up until the first diagnosis of mental disorders or the end of the follow up. The primary outcome was a composite of incident mood, anxiety, stress-related, or somatoform disorders. Secondary outcomes included two components of the primary outcome (i.e. mood disorders and anxiety/stress-related/somatoform disorders). During a median follow-up period of 4.1 years, the incidence rate of the primary outcome was 54.4 and 31.5/1000 person-years among the HCM and control groups, respectively, resulting in a hazard ratio (HR) of 1.719 (95% confidence interval: 1.589-1.860). Within the first month after HCM diagnosis, the HR for the primary outcome was 3.074 (2.096-4.508). Beyond 1 month, the HRs decreased, ranging from 2.281 (1.952-2.665) during 1-12 months, to 2.087 (1.831-2.380) during 12-36 months and 1.258 (1.090-1.452) after 36 months of follow up. Similar results were observed for the secondary outcomes. In sensitivity analysis, the risk of the specific categories of mental disorders, including single or recurrent depressive episodes and anxiety disorders, was also higher in patients with HCM than matched controls. CONCLUSION: HCM was significantly associated with the risk of incident mental disorders, particularly within 1 year after HCM diagnosis, underscoring the importance of screening mental health problems, including mood and anxiety disorders, in patients with HCM.
Park et al. (Wed,) conducted a cohort in Hypertrophic cardiomyopathy (n=16,184). Hypertrophic cardiomyopathy vs. Matched individuals without HCM was evaluated on Composite of incident mood, anxiety, stress-related, or somatoform disorders (HR 1.719, 95% CI 1.589-1.860). Hypertrophic cardiomyopathy was significantly associated with an increased risk of incident mental disorders compared to matched controls (HR 1.719; 95% CI 1.589-1.860).
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