High-resolution slice-to-slice histology demonstrates that deeper penetration of fibrosis in the subepicardial and midwall layers of dilated atria may contribute to a 3D arrhythmic substrate.
Quantification of fibrosis transmural profile at high resolution is feasible by slice-to-slice histology. Deeper penetration of fibrosis in subepicardial and midwall layers in dilated atria may concur to the formation of a 3D arrhythmic substrate.
Ravelli et al. (Wed,) studied this question.