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Objectives 18 F-fluorodeoxyglucose (FDG) PET/CT has been widely used in tumor diagnosis, staging, and response evaluation. To determine an optimal therapeutic strategy for lung cancer patients, accurate staging is essential. Semi-quantitative standardized uptake value (SUV) is known to be affected by multiple factors and may fail to differentiate between benign and malignant lesions. Lymph nodes (LNs) in the mediastinal and pulmonary hilar regions with high FDG uptake due to granulomatous lesions such as tuberculosis, which has a high prevalence in China, pose a diagnostic challenge. This study aims to evaluate the diagnostic value of the quantitative metabolic parameters derived from dynamic 18 F-FDG PET/CT in differentiating metastatic and non-metastatic LNs in lung cancer. Methods One hundred and eight patients with pulmonary nodules were enrolled to perform 18 F-FDG PET/CT dynamic + static imaging with informed consent. One hundred and thirty-five LNs in 29 lung cancer patients were confirmed by pathology. Static image analysis parameters including LN-SUVmax, LN-SUVmax/primary tumor SUVmax (LN-SUVmax/PT-SUVmax), mediastinal blood pool SUVmax (MBP-SUVmax), LN-SUVmax/MBP-SUVmax, and LN-SUVmax/short diameter. Quantitative parameters including K 1 , k 2 , k 3 and K i and of each LN were obtained by applying the irreversible two-tissue compartment model using in-house Matlab software. K i /K 1 was computed subsequently as a separate marker. We further divided the LNs into mediastinal LNs ( N =82) and pulmonary hilar LNs ( N =53). Wilcoxon rank-sum test or Independent-samples T-test and receiver-operating characteristic (ROC) analysis was performed on each parameter to compare the diagnostic efficacy in differentiating lymph node metastases from inflammatory uptake. P 0.05 were considered statistically significant. Results Among the 135 FDG-avid LNs confirmed by pathology, 49 LNs were non-metastatic, and 86 LNs were metastatic. LN-SUVmax, MBP-SUVmax, LN-SUVmax/MBP-SUVmax, and LN-SUVmax/short diameter couldn’t well differentiate metastatic from non-metastatic LNs ( P 0.05). However, LN-SUVmax/PT-SUVmax have good performance in the differential diagnosis of non-metastatic and metastatic LNs ( P =0.039). Dynamic metabolic parameters in addition to k 3 , the parameters including K 1 , k 2 , K i , and K i /K 1 , on the other hand, have good performance in the differential diagnosis of metastatic and non-metastatic LNs ( P =0.045, P =0.001, P =0.001, P =0.001, respectively). For ROC analysis, the metabolic parameters K i (AUC of 0.672 0.579-0.765, sensitivity 0.395, specificity 0.918) and K i /K 1 (AUC of 0.673 0.580-0.767, sensitivity 0.570, specificity 0.776) have good performance in the differential diagnosis of metastatic from non-metastatic LNs than SUVmax (AUC of 0.596 0.498-0.696, sensitivity 0.826, specificity 0.388), included the mediastinal region and pulmonary hilar region. Conclusion Compared with SUVmax, quantitative parameters such as K 1 , k 2 , K i and K i /K 1 showed promising results for differentiation of metastatic and non-metastatic LNs with high uptake. The K i and K i /K 1 had a high differential diagnostic value both in the mediastinal region and pulmonary hilar region.
Wumener et al. (Thu,) studied this question.