November 16, 2022Open Access

Risk factors for venous thromboembolism following surgical treatment of fractures: A systematic review and meta‐analysis

ZXZhen‐Hua XiaHuadong Hospital WCWeihua ChenHebei Medical University QWQun WangLiaoning University

Structured PICO

What are the clinical risk factors associated with postoperative venous thromboembolism in patients undergoing surgical treatment for fractures?

Population

3,239,291 patients treated surgically for fractures across 44 studies

Intervention

Presence of various clinical risk factors (e.g., elderly, ASA ≥ 3, blood transfusion, cardiovascular disease, elevated D-dimer, diabetes, hypertension, immobility, lung disease, obesity, peripheral artery disease, prior thromboembolic event, steroid use, regional anesthesia)

Comparator

Absence of these risk factors

Outcome

Postoperative venous thromboembolism (VTE)hard clinical

Multiple patient and clinical factors, notably prior thromboembolic events and elevated D-dimer, significantly increase the risk of VTE following fracture surgery, highlighting the need for targeted risk stratification and prophylaxis.

Abstract

This study aimed to determine the risk factors for postoperative venous thromboembolism (VTE) in patients treated surgically for fractures using a meta-analytic approach. Electronic searches were performed in PubMed, Embase, and the Cochrane library from inception until February 2022. The odds ratio (OR) and 95% confidence interval (CI) were applied to calculate the pooled effect estimate using the random-effects model. Sensitivity, subgroup, and publication bias tests were also performed. Forty-four studies involving 3 239 291 patients and reporting 11 768 VTE cases were selected for the meta-analysis. We found that elderly (OR: 1.72; 95% CI: 1.38-2.15; P < .001), American Society of Anesthesiologists (ASA) ≥ 3 (OR: 1.82; 95% CI: 1.46-2.29; P < .001), blood transfusion (OR: 1.82; 95% CI: 1.14-2.92; P = .013), cardiovascular disease (CVD) (OR: 1.40; 95% CI: 1.22-1.61; P < .001), elevated D-dimer (OR: 4.55; 95% CI: 2.08-9.98; P < .001), diabetes mellitus (DM) (OR: 1.36; 95% CI: 1.19-1.54; P < .001), hypertension (OR: 1.31; 95% CI: 1.09-1.56; P = .003), immobility (OR: 3.45; 95% CI: 2.23-5.32; P < .001), lung disease (LD) (OR: 2.40; 95% CI: 1.29-4.47; P = .006), obesity (OR: 1.52; 95% CI: 1.27-1.82; P < .001), peripheral artery disease (PAD) (OR: 2.13; 95% CI: 1.21-3.73; P = .008), prior thromboembolic event (PTE) (OR: 5.17; 95% CI: 3.14-8.50; P < .001), and steroid use (OR: 2.37; 95% CI: 1.73-3.24; P < .001) were associated with an increased risk of VTE. Additionally, regional anaesthesia (OR: 0.66; 95% CI: 0.45-0.96; P = .029) was associated with a reduced risk of VTE following surgical treatment of fractures. However, alcohol intake, cancer, current smoking, deep surgical site infection, fusion surgery, heart failure, hypercholesterolemia, liver and kidney disease, sex, open fracture, operative time, preoperative anticoagulant use, rheumatoid arthritis, and stroke were not associated with the risk of VTE. Post-surgical risk factors for VTE include elderly, ASA ≥ 3, blood transfusion, CVD, elevated D-dimer, DM, hypertension, immobility, LD, obesity, PAD, PTE, and steroid use.

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